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Review
. 2018 Apr 25;82(5):1237-1244.
doi: 10.1253/circj.CJ-17-0242. Epub 2017 Sep 14.

Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation

Yung-Kuo Lin  1   2 , Yi-Ann Chen  3 , Ting-I Lee  4 , Yao-Chang Chen  5 , Shih-Ann Chen  6 , Yi-Jen Chen  1   7
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Free article
Review

Aging Modulates the Substrate and Triggers Remodeling in Atrial Fibrillation

Yung-Kuo Lin et al. Circ J. .
Free article

Abstract

Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.

Keywords: Aging; Atria; Atrial fibrillation; Pulmonary veins.

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