Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Aug 23:2:67.
doi: 10.21037/tgh.2017.08.01. eCollection 2017.

Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

Priscilla Régia de Andrade Calaça  1   2 , Raquel Pedrosa Bezerra  1   2 , Wendell Wagner Campos Albuquerque  1 , Ana Lúcia Figueiredo Porto  1   2   3 , Maria Taciana Holanda Cavalcanti  1   2
Affiliations

Probiotics as a preventive strategy for surgical infection in colorectal cancer patients: a systematic review and meta-analysis of randomized trials

Priscilla Régia de Andrade Calaça et al. Transl Gastroenterol Hepatol. .

Abstract

Background: Infection following abdominal surgery remains a major factor in morbidity among colorectal cancer (CRC) patients. Probiotic therapy has been suggested to improve the clinical and laboratory outcome of patients undergoing gastrointestinal surgery. The aim of this study was to investigate the efficacy of probiotic lactic acid bacteria in patients with CRC in the pre- and postoperative phases.

Methods: Systematic database searches identified 1,080 related articles. However, only seven articles were selected according to the eligibility criteria for qualitative and quantitative evaluation.

Results: Most of the reviewed articles presented satisfactory results related to the prevention of surgical inflammation in patients undergoing resection of CRC when using strains of Lactobacillus genus, predominantly.

Conclusions: Probiotics are suggested to prevent surgical inflammation of CRC, at the same time that the combination of particular microorganisms administered is beneficial to the treatment and surgical recovery.

Keywords: Colorectal cancer (CRC); meta-analysis; perioperative; probiotics.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Flow diagram for study identification and selection [adapted from Moher et al. (12)].
Figure 2
Figure 2
“Forest plot” effect of probiotics compared to the control group in the pre and postoperative treatment in accordance with the primary objective of the clinical trials in patients with CRC for incisional infection (5,6,18,19). CRC, colorectal cancer.
Figure 3
Figure 3
Detection of bacteria in the blood according to the administration of probiotics in the perioperative period, compared to the control group with the primary objective of the clinical trials in patients with CRC (2,4,5,9,18,19). CRC, colorectal cancer.
Figure 4
Figure 4
Effect of probiotics to minimize complications of infection “Forest plot” compared to the control group in the pre and postoperative treatment in accordance with the primary objective of the clinical trials in patients with CRC (2,4-6,9,18,19). CRC, colorectal cancer.
See this image and copyright information in PMC

References

    1. Desrouillères K, Millette M, Dang Vu K, et al. Cancer preventive effects of a specific probiotic fermented milk containing Lactobacillus acidophilus CL1285, L. casei LBC80R and L. rhamnosus CLR2 on male F344 rats treated with 1,2-dimethylhydrazine. J Funct Foods 2015;17:816-27. 10.1016/j.jff.2015.06.035 - DOI
    1. Liu Z, Li C, Huang M, et al. Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial. BMC Gastroenterol 2015;15:34. 10.1186/s12876-015-0260-z - DOI - PMC - PubMed
    1. Addae JK, Gani F, Fang SY, et al. A comparison of trends in operative approach and postoperative outcomes for colorectal cancer surgery. J Surg Res 2017;208:111-20. 10.1016/j.jss.2016.09.019 - DOI - PubMed
    1. Liu Z, Qin H, Yang Z, et al. Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery-a double-blind study. Aliment Pharmacol Ther 2011;33:50-63. 10.1111/j.1365-2036.2010.04492.x - DOI - PubMed
    1. Liu ZH, Huang MJ, Zhang XW, et al. The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. Am J Clin Nutr 2013;97:117-26. 10.3945/ajcn.112.040949 - DOI - PubMed

LinkOut - more resources