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. 1987 Nov;77(3):233-5.
doi: 10.1007/BF00284475.

Linkage relationships of X-linked choroideremia to DXYS1 and DXS3

I M MacDonald  1 , R M Sandre, P Wong, A G Hunter, M P Tenniswood
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Linkage relationships of X-linked choroideremia to DXYS1 and DXS3

I M MacDonald et al. Hum Genet. 1987 Nov.

Abstract

Choroideremia is a distinct blinding condition with an X-linked pattern of inheritance. We have analyzed two RFLPs, DXS3 and DXYS1, for linkage with the choroideremia locus (TCD) within three kindreds. A maximum LOD score of 3.98 was obtained at theta = 0.14 for TCD:DXS3. The summed maximum LOD score from this study and from previously published TCD:DXYS1 data is 5.23 at theta = 0.05. Contrary to previous reports, the present data demonstrate that these two RFLPs are not tightly linked to the choroideremia gene locus.

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References

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