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Review
. 2018 Jan 1;197(1):22-37.
doi: 10.1164/rccm.201611-2232PP.

Eosinophilic and Noneosinophilic Asthma

Tara F Carr  1 , Amir A Zeki  2 , Monica Kraft  1
Affiliations
Review

Eosinophilic and Noneosinophilic Asthma

Tara F Carr et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic representation of asthma and the spectrum of inflammation type and endotypes underlying clinical phenotypes. T2 = type 2; Th2 = T-helper type 2 cell. Adapted by permission from Reference .
Figure 2.
Figure 2.
Mechanisms of eosinophilic asthma. DAMP = damage-associated molecular patterns; ETE = eicosatetraenoic acid; HETE = hydroxyeicosatetraenoic acid; LT = leukotriene; MEK = MAPK/ERK kinase; Th = T-helper cell; TSLP = thymic stromal lymphopoeitin.
Figure 3.
Figure 3.
Mechanisms of noneosinophilic asthma. CRP = C-reactive protein; CXCR2 = chemokine receptor 2; DAMP = damage-associated molecular patterns; dsRNA = double-stranded RNA; HETE = hydroxyeicosatetraenoic acid; MAPK = mitogen-activated protein kinase; NF-κB = nuclear factor κB; NK = natural killer; sEH = soluble epoxide hydrolase; Tc1 = cytotoxic T-cell subset 1; Th = T-helper cell; TLR4 = toll-like receptor 4; TNFα = tumor necrosis factor-α.
Figure 4.
Figure 4.
Clinical phenotypes, endotypes, and therapeutic options in eosinophilic and noneosinophilic asthma. CRTH2 = chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells; CXCR2 = chemokine receptor 2; DPP4 = dipeptidyl peptidase-4; FeNO = fractional exhaled nitric oxide; GM-CSF = granulocyte–macrophage colony–stimulating factor; ILC = innate lymphoid cell; NK = natural killer; NKT = natural killer-T; PGD2 = prostaglandin D2; PPARγ = peroxisome proliferator-activated receptor-γ; Th = T-helper cell; TNFα = tumor necrosis factor-α; TSLP = thymic stroll lymphopoeitin.
See this image and copyright information in PMC

References

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