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. 2017 Jun;14(2):89-93.
doi: 10.4274/tjod.61224. Epub 2017 Jun 15.

Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance

Gönül Erkan  1 , Ahter Tanay Tayyar  2 , Gökhan Açmaz  3 , İptisam İpek Müderris  4 , Gülden Başkol  5 , Fahri Bayram  6
Affiliations

Role of osteocalcin, tumor necrosis factor-alpha and adiponectin in polycystic ovary syndrome patients with insulin resistance

Gönül Erkan et al. Turk J Obstet Gynecol. 2017 Jun.

Abstract

Objective: Insulin resistance (IR) seems to be the main pathogenic factor in polycystic ovary syndrome (PCOS). Adiponectin and tumor necrosis factor-alpha (TNF-α) are important in IR. The aim of this study was to evaluate the correlations of osteocalcin, adiponectin, and TNF-α with IR in PCOS.

Materials and methods: A total of 60 women were divided into two groups. The first group constituted 44 patients with PCOS and the control group comprised 16 healthy women. Osteocalcin, adiponectin, TNF-α levels, body mass index (BMI), and IR in the fasting state were assessed and correlations of these parameters were evaluated.

Results: Homeostasis model assessment (HOMA)-IR, adiponectin, osteocalcin, and androstenedione levels were significantly increased in the PCOS group. A moderate positive correlation between BMI and HOMA-IR, a moderate negative correlation between TNF-α and osteocalcin, and a mild negative correlation between adiponectin and BMI were detected in PCOS.

Conclusion: Osteocalcin may have impact on adiponectin, TNF-α, and IR levels in PCOS. Different osteocalcin levels in patients with PCOS may be responsible for explaining PCOS heterogeneity.

Keywords: Adiponectin; Polycystic ovary syndrome; insulin resistance; osteocalcin; tumor necrosis factor-alpha.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1. A scatterplot matrix displaying the relationship among body mass index, homeostasis model assessment-insulin resistance, tumor necrosis factor-alpha, adiponectin, and osteocalcin variables *p<0.05, **p<0.01 HOMA-IR: Homeostasis model assessment-insulin resistance, BMI: Body mass index, TNF-α: Tumor necrosis factor-alpha
See this image and copyright information in PMC

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