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. 2016 Sep 5:2:2333721416665502.
doi: 10.1177/2333721416665502. eCollection 2016 Jan-Dec.

Evaluating PROMIS Physical Function Measures in Older Adults at Risk for Alzheimer's Disease

Curtis Tatsuoka  1   2 , Louis DeMarco  1 , Kathleen A Smyth  1 , Stephen Wilkes  2 , Molly Howland  1 , Alan J Lerner  1   2 , Martha Sajatovic  1   2
Affiliations

Evaluating PROMIS Physical Function Measures in Older Adults at Risk for Alzheimer's Disease

Curtis Tatsuoka et al. Gerontol Geriatr Med. .

Abstract

Activities of daily living can be affected by cognitive decline. Self-report measurement of functioning is attractive due to ease of data collection, low cost, and accessibility via technology-assisted means, and for understanding patient perspective. A concern is with reliability of such measurement as cognitive decline occurs. We compared a widely used, self-report "legacy" measure of functioning, Lawton and Brody's Instrumental Activities of Daily Living Scale (IADLS), with a subset of physical functioning items from the Patient-Reported Outcomes Measurement Information System (PROMIS). The study sample consisted of 304 individuals of varying cognitive status: normal, mild cognitive impairment (MCI), or early dementia. An expert consensus method was used to select PROMIS functional items most relevant to neurocognitive disorder and to identify major functional sub-domains. Selected PROMIS functional subscales and the IADLS were then evaluated with respect to cognitive status. Few PROMIS functional items were useful in identifying MCI, while we reaffirmed the utility of the IADLS. Also, even mild depression levels were found to have negative effects on functioning according to both PROMIS and IADLS.

Keywords: MCI; PROMIS; dementia; physical functioning; self-report measurement.

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Conflict of interest statement

Declaration of Conflicting Interests: The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr. Tatsuoka reports the following conflicts of interest: Research grants within the past 3 years: Philips Healthcare, Biogen, and National Science Foundation. Dr. Sajatovic reports the following conflicts of interest: Research grants within past 3 years: Pfizer, Merck, Ortho-McNeil Janssen, Janssen, Reuter Foundation, Woodruff Foundation, Reinberger Foundation, National Institute of Health (NIH), and Centers for Disease Control and Prevention (CDC); Consultant: Bracket, Prophase, Otsuka, Pfizer, Sunovion, and Neurocrine; Royalties: Springer Press, Johns Hopkins University Press, Oxford Press, UpToDate, Lexicomp, and Continuing Medical Education (CME); activities: American Physician’s Institute, MCM Education, and CMEology. Dr. Lerner reports the following conflicts of interest: Research grants within past 3 years: NIH, Eli Lilly, Toyama Chemical Co., and TauRX.

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