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. 2014 Oct;21(2):118-122.

Biomarkers in polytrauma induced systemic inflammatory response syndrome and sepsis - a narrative review

Sebastian Daniel Trancă  1 , Cristina Laura Petrişor  1 , Natalia Hagău  1
Affiliations

Biomarkers in polytrauma induced systemic inflammatory response syndrome and sepsis - a narrative review

Sebastian Daniel Trancă et al. Rom J Anaesth Intensive Care. 2014 Oct.

Abstract
in English, Romanian

Polytrauma still represents one of the leading causes of death in the first four decades of life. Septic complications represent the predominant causes of late death in polytrauma patients. Early diagnosis and treatment of infection is associated with an improved clinical outcome and reduced mortality. Several biomarkers have been evaluated for making early diagnosis of sepsis. Current evidence does not support the use of a single biomarker in diagnosing septic complications. Procalcitonin trend was found to be useful in early identification of post-traumatic sepsis.

Politrauma continuă să reprezinte una din principalele cauze de deces în primele patru decenii de viaţă. Complicaţiile septice reprezintă cauzele preponderente de deces tardiv în cazul pacienţilor politraumatizaţi. Diagnosticul precoce şi tratamentul infecţiei este asociat cu o evoluţie clinică favorabilă şi o mortalitate redusă. Diferiţi biomarkeri au fost evaluaţi în scopul diagnosticului precoce al sepsisului. Indiciile actuale nu susţin un anume biomarker pentru diagnosticul complicaţiilor septice. Opţiunea pentru procalcitonină s-a dovedit utilă ca element de diagnosticare precoce a sepsisului posttraumatic.

Keywords: cytokine; multiple trauma; sepsis; systemic inflammatory response syndrome.

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Conflict of interest statement

Conflict of interest Nothing to declare

Figures

Fig. 1
Fig. 1
Biomarkers plasma concentrations profile in patients with multiple trauma-induced systemic inflammatory response syndrome. IL-1 = interleukine 1; IL-6 = interleukine 6; TNFα = tumoral necrosis factor alpha; PCT = procalcitonin; CRP = C-reactive protein. Plasma concentrations are expressed in grey-scale as a colour gradient, peak concentrations being represented as black
See this image and copyright information in PMC

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