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. 2017 Nov;9(6):534-539.
doi: 10.4168/aair.2017.9.6.534.

A Retrospective Study of Korean Adults With Food Allergy: Differences in Phenotypes and Causes

So Hee Lee #  1 , Ga Young Ban #  1 , Kyunguk Jeong  2 , Yoo Seob Shin  1 , Hae Sim Park  1 , Sooyoung Lee  3 , Young Min Ye  4
Affiliations

A Retrospective Study of Korean Adults With Food Allergy: Differences in Phenotypes and Causes

So Hee Lee et al. Allergy Asthma Immunol Res. 2017 Nov.

Abstract

Purpose: Increasing in prevalence, food allergy (FA) is becoming an important public health concern. In Korean adults, however, clinical phenotypes and causes of FA have not been studied. We aimed to study common causative allergens and clinical manifestations of FA in Korean adults.

Methods: This study was conducted as a retrospective review of medical records for 95 patients (≥19 years old) diagnosed with FA from September 2014 to August 2015 at a single university hospital.

Results: In the 95 patients, 181 FA events were recorded. The mean age of first onset of FA symptoms was 34.7±15.8 years. The most frequent causative food was seafood (34.8%); shrimp and crab allergies ranked highest, regardless of age and sex. Among all FA events, there were 47 (26.0%) cases of anaphylaxis and 26 (14.4%) cases of oral allergy syndrome (OAS). Seafood (51.1%) was the most frequent cause of anaphylaxis, followed by grains (14.9%). Most OAS cases were associated with fruits (95.7%). The frequency of fruit-induced FA was significantly higher in males than in females (23.0% vs 8.4%, P=0.011). While no cases of vegetables-induced FA were noted in younger individuals (19 to 30 years), vegetables accounted for 20.5% of FA symptoms in older subjects (≥51 years, P<0.001). Allergic rhinitis (44.2%) and drug allergy (20.0%) were major comorbidities associated with FA. Overall, 29 FA events had cofactors, of which 10 were combined with exercise.

Conclusions: The major causes of FA in Korean adults were crustacean, fruits, and grains. Interestingly, the clinical manifestations of FA and demographics varied according to type of food allergen.

Keywords: Food allergy; Korea; adults.

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Conflict of interest statement

There are no financial or other issues that might lead to conflict of interest.

Figures

Fig. 1
Fig. 1. Causes of food allergy in adults.
Fig. 2
Fig. 2. Comparison of major causative foods between male and female adults. *P value <0.05. NBS, nuts-beans-seeds.
See this image and copyright information in PMC

References

    1. Mullins RJ, Dear KB, Tang ML. Time trends in Australian hospital anaphylaxis admissions in 1998-1999 to 2011-2012. J Allergy Clin Immunol. 2015;136:367–375. - PubMed
    1. Sicherer SH, Sampson HA. Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 2014;133:291–307. - PubMed
    1. Park M, Kim D, Ahn K, Kim J, Han Y. Prevalence of immediate-type food allergy in early childhood in Seoul. Allergy Asthma Immunol Res. 2014;6:131–136. - PMC - PubMed
    1. Hong SJ, Ahn KM, Lee SY, Kim KE. The prevalences of asthma and allergic diseases in Korean children. Korean J Pediatr. 2008;51:343–350.
    1. Branum AM, Lukacs S. In: Food allergy among U.S. children: trends in prevalence and hospitalizations. Lukacs S, editor. Atlanta (GA): Centers for Disease Control and Prevention; 2008. - PubMed