doi: 10.1016/0165-3806(87)90030-7.
The effects of excitatory amino acids and their antagonists on the generation of motor activity in the isolated chick spinal cord
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- PMID: 2891412
- DOI: 10.1016/0165-3806(87)90030-7
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The effects of excitatory amino acids and their antagonists on the generation of motor activity in the isolated chick spinal cord
Brain Res.
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Abstract
We have investigated the action of excitatory amino acids and their antagonists on spontaneous motor activity produced by an isolated preparation of the chick lumbosacral cord. Bath application of N-methyl-DL-aspartic acid (NMDA) or D-glutamate increased the occurrence and duration of spontaneous episodes of motor activity. Both NMDA-induced and spontaneous activity were reversibly inhibited by several excitatory amino acid antagonists including 2-amino-5-phosphono valeric acid and gamma-D-glutamyl glycine in a dose-dependent manner. These results suggest that motor activity in the chick spinal cord may be regulated by the release of endogenous excitatory amino acids from spinal interneurons.
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