. 2018 Jan;32(1):237-241.

doi: 10.1038/leu.2017.282. Epub 2017 Sep 15.

Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia

M Waibel^{1

2

3}, S J Vervoort^{1

2

3}, I Y Kong^{4

5}, S Heinzel^{4

5}, K M Ramsbottom², B P Martin¹, E D Hawkins^{4

5}, R W Johnstone^{1

2

3}

Affiliations

¹ Cancer Therapeutics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
² Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
³ Sir Peter MacCallum Department of Oncology, The University of Melbourne, Australia.
⁴ The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia and.
⁵ Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.

PMID: 28914259
DOI: 10.1038/leu.2017.282

Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia

M Waibel et al. Leukemia. 2018 Jan.

. 2018 Jan;32(1):237-241.

doi: 10.1038/leu.2017.282. Epub 2017 Sep 15.

Authors

M Waibel^{1

2

3}, S J Vervoort^{1

2

3}, I Y Kong^{4

5}, S Heinzel^{4

5}, K M Ramsbottom², B P Martin¹, E D Hawkins^{4

5}, R W Johnstone^{1

2

3}

Affiliations

¹ Cancer Therapeutics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
² Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
³ Sir Peter MacCallum Department of Oncology, The University of Melbourne, Australia.
⁴ The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia and.
⁵ Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.

PMID: 28914259
DOI: 10.1038/leu.2017.282

No abstract available

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References

1. Mol Cell Biol. 2000 Oct;20(20):7505-15 - PubMed
1. Blood. 2013 Oct 3;122(14):2331-7 - PubMed
1. Nat Commun. 2015 Apr 27;6:6838 - PubMed
1. Lancet Haematol. 2015 Aug;2(8):e326-33 - PubMed
1. Lancet. 2008 Mar 22;371(9617):1030-43 - PubMed

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Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia

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Epigenetic targeting of Notch1-driven transcription using the HDACi panobinostat is a potential therapy against T-cell acute lymphoblastic leukemia

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