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. 2018 Jun;20(6):655-663.
doi: 10.1038/gim.2017.144. Epub 2017 Sep 14.

Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working Group

Lori A Orlando  1 , Nina R Sperber  2 , Corrine Voils  2 , Marshall Nichols  1 , Rachel A Myers  1 , R Ryanne Wu  1 , Tejinder Rakhra-Burris  1 , Kenneth D Levy  3 , Mia Levy  4 , Toni I Pollin  5 , Yue Guan  5 , Carol R Horowitz  6 , Michelle Ramos  6 , Stephen E Kimmel  7 , Caitrin W McDonough  8 , Ebony B Madden  9 , Laura J Damschroder  10   11
Affiliations

Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working Group

Lori A Orlando et al. Genet Med. 2018 Jun.

Erratum in

Abstract

PurposeImplementation research provides a structure for evaluating the clinical integration of genomic medicine interventions. This paper describes the Implementing Genomics in Practice (IGNITE) Network's efforts to promote (i) a broader understanding of genomic medicine implementation research and (ii) the sharing of knowledge generated in the network.MethodsTo facilitate this goal, the IGNITE Network Common Measures Working Group (CMG) members adopted the Consolidated Framework for Implementation Research (CFIR) to guide its approach to identifying constructs and measures relevant to evaluating genomic medicine as a whole, standardizing data collection across projects, and combining data in a centralized resource for cross-network analyses.ResultsCMG identified 10 high-priority CFIR constructs as important for genomic medicine. Of those, eight did not have standardized measurement instruments. Therefore, we developed four survey tools to address this gap. In addition, we identified seven high-priority constructs related to patients, families, and communities that did not map to CFIR constructs. Both sets of constructs were combined to create a draft genomic medicine implementation model.ConclusionWe developed processes to identify constructs deemed valuable for genomic medicine implementation and codified them in a model. These resources are freely available to facilitate knowledge generation and sharing across the field.

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Conflict of interest statement

CONFLICTS OF INTEREST

None of the authors have any conflicts of interest as relates to the work presented in this paper.

Figures

Figure 1
Figure 1
Common Measures Working Group Process Plan for Developing Common Measures
Figure 2
Figure 2. The Consolidated Framework for Implementation Research
Bolded constructs are those identified as high priority by IGNITE.
Figure 3
Figure 3
Genomic Medicine Implementation Model Developed as part of the IGNITE Network
See this image and copyright information in PMC

References

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