Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Oct;70(1):152-7.

T cell receptor beta chain polymorphisms are associated with insulin-dependent diabetes

B A Millward  1 , K I Welsh, R D Leslie, D A Pyke, A G Demaine
Affiliations

T cell receptor beta chain polymorphisms are associated with insulin-dependent diabetes

B A Millward et al. Clin Exp Immunol. 1987 Oct.

Abstract

We investigated the T cell receptor constant beta chain (TCR C beta) genes of patients with insulin dependent diabetes mellitus (IDDM) using DNA restriction fragment length polymorphism (RFLP) analysis. Genomic DNA from patients and controls was digested with the restriction endonuclease Bg1 II and transferred to nylon filters using the Southern blot procedure. This enzyme identifies a polymorphic site between the two TCR C beta chain genes. We have found a highly significant increase in the frequency of the 10.0; 9.2 kilobase heterozygous phenotype in patients with IDDM (62.7% versus 42.0% in normal controls; P = 0.0006). In identical twin pairs, this association was most striking in those concordant for IDDM (79.2% versus 42.0% in controls; P = 0.0006).

PubMed Disclaimer

References

    1. Lancet. 1974 Nov 30;2(7892):1279-83 - PubMed
    1. Nature. 1984 Mar 8-14;308(5955):145-9 - PubMed
    1. Acta Genet Stat Med. 1961;11:338-62 - PubMed
    1. Clin Exp Immunol. 1986 Nov;66(2):406-13 - PubMed
    1. Anal Biochem. 1984 Feb;137(1):266-7 - PubMed

Publication types

Substances

LinkOut - more resources