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Review
. 2017 Sep 12;7(4):1479-1495.
doi: 10.1002/cphy.c170017.

Air Pollution and Other Environmental Modulators of Cardiac Function

Matthew W Gorr  1   2 , Michael J Falvo  3   4 , Loren E Wold  1   2   5
Affiliations
Review

Air Pollution and Other Environmental Modulators of Cardiac Function

Matthew W Gorr et al. Compr Physiol. .

Abstract

Cardiovascular disease (CVD) is the leading cause of death in developed regions and a worldwide health concern. Multiple external causes of CVD are well known, including obesity, diabetes, hyperlipidemia, age, and sedentary behavior. Air pollution has been linked with the development of CVD for decades, though the mechanistic characterization remains unknown. In this comprehensive review, we detail the background and epidemiology of the effects of air pollution and other environmental modulators on the heart, including both short- and long-term consequences. Then, we provide the experimental data and current hypotheses of how pollution is able to cause the CVD, and how exposure to pollutants is exacerbated in sensitive states. Published 2017. Compr Physiol 7:1479-1495, 2017.

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Figures

Figure 1
Figure 1
Overall schematic of proposed environmental modulators of cardiovascular health.
See this image and copyright information in PMC

References

    1. Agrawal S, Yamamoto S. Effect of Indoor air pollution from biomass and solid fuel combustion on symptoms of preeclampsia/eclampsia in Indian women. Indoor Air 25: 341–352, 2015. - PMC - PubMed
    1. Alexis NE, Lay JC, Zeman K, Bennett WE, Peden DB, Soukup JM, Devlin RB, Becker S. Biological material on inhaled coarse fraction particulate matter activates airway phagocytes in vivo in healthy volunteers. J Allergy Clin Immunol 117: 1396–1403, 2006. - PubMed
    1. Anselme F, Loriot S, Henry J-P, Dionnet F, Napoleoni J-G, Thuillez C, Morin J-P. Inhalation of diluted diesel engine emission impacts heart rate variability and arrhythmia occurrence in a rat model of chronic ischemic heart failure. Arch Toxicol 81: 299–307, 2006. - PubMed
    1. Araujo J a, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res 102: 589–596, 2008. - PMC - PubMed
    1. Auchincloss AH, Diez Roux AV, Dvonch JT, Brown PL, Barr RG, Daviglus ML, Goff DC, Kaufman JD, O’Neill MS. Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-ethnic Study of Atherosclerosis (MESA). Environ Health Perspect 116: 486–491, 2008. - PMC - PubMed

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