[Effect of nonselective and cardioselective beta-adrenergic blockade on fatty acid metabolism in the myocardium]

Abstract

Effects of beta-adrenoblocker obsidan and selective beta-adrenoblocker cordanum on metabolism of fatty acids in the rat myocardium were studied. Obsidan increased the concentration of triglycerides and decreased that of nonesterified fatty acids in the myocardial tissue, reduced the amounts of ketone bodies, beta-oxybutyrate and acetoacetate, accelerated oxidation of fatty acids by myocardial mitochondria. Cordanum produced no changes in beta-oxybutyrate concentration, decreased the concentrations of acetoacetate, induced accumulation of triglycerides. The drug reduced respiration control at the expense of an increase in controlled respiration rate. Thus, in contrast to total beta-adrenergic blockade induced by obsidan, cardioselective beta-adrenergic blockade by cordanum results in a decrease of myocardial oxygen consumption and a reduction of respiration controlled respiration rate.