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. 1988;27(2):87-90.
doi: 10.1007/BF00351080.

Taq I-generated HLA-DQ alpha polymorphism in Japanese patients with narcolepsy

K Matsuki  1 , H Maeda, T Juji, H Inoko, A Ando, K Tsuji, Y Honda
Affiliations

Taq I-generated HLA-DQ alpha polymorphism in Japanese patients with narcolepsy

K Matsuki et al. Immunogenetics. 1988.

Abstract

Taq I-generated HLA-DQ alpha restriction fragment length polymorphism was examined in Japanese patients with narcolepsy. All patients were DR2 positive and shared a 6.0 kb fragment, although this fragment was found only in 54% of the healthy DR2-positive Japanese. This finding added the DQ alpha gene to the list of candidates for the possible narcolepsy-susceptibility gene. In contrast, there was no complete association between narcolepsy and DX alpha restriction fragment length polymorphism. These findings suggest that a narcolepsy-susceptibility gene is located closer to the DQ locus than to the DX locus.

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