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. 1988;27(2):96-101.
doi: 10.1007/BF00351082.

The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes

Y Uematsu  1 , K Fischer Lindahl, M Steinmetz
Affiliations

The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes

Y Uematsu et al. Immunogenetics. 1988.

Abstract

Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the A beta 2 gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/A beta 3 and A beta 3/A beta 2 recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.

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