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. 2018 Jan;141(1):429-432.
doi: 10.1016/j.jaci.2017.07.039. Epub 2017 Sep 12.

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort

Carlos H Martinez  1 , Sara X Li  1 , Andrew J Hirzel  1 , Valerie R Stolberg  2 , Neil E Alexis  3 , R Graham Barr  4 , Eugene R Bleecker  5 , Elizabeth E Carretta  3 , Stephanie A Christenson  6 , Christopher B Cooper  7 , David J Couper  3 , Claire M Doerschuk  3 , MeiLan K Han  1 , Nadia N Hansel  8 , Annette T Hastie  5 , Eric A Hoffman  9 , Robert J Kaner  10 , Fernando J Martinez  10 , Deborah A Meyers  5 , Wanda K O'Neal  3 , Robert Paine 3rd  11 , Nirupama Putcha  8 , Stephen I Rennard  12 , Prescott G Woodruff  6 , Michelle Zeidler  7 , Jeffrey L Curtis  13 , Christine M Freeman  14 ; SPIROMICS Investigators
Affiliations

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort

Carlos H Martinez et al. J Allergy Clin Immunol. 2018 Jan.

Abstract

Active smoking in stable COPD subjects significantly increased eosinophil accumulation in the distal airspaces, but not in sputum or peripheral blood. Our findings support the need to investigate this cell-type as a potential driver of COPD symptomatology and progression.

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Figures

Figure 1
Figure 1. Active smoking significantly increases BAL eosinophil percentages in COPD
Flow cytometric analysis of eosinophils in (A) blood (n=97), (B) sputum (n=94) and (C) BAL (n=91). NS, never-smokers; FS-NAO, former smokers, no airflow obstruction; CS-NAO, current smokers, no airflow obstruction; FS-COPD, former smokers with COPD; CS-COPD, current smokers with COPD. Box and whiskers plot showing median ± interquartile range, 5th and 95th percentiles, with outliers shown as symbols. *, p<0.05; **, p<0.01; ANOVA with Holm-Sidak post-hoc testing.
See this image and copyright information in PMC

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