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Review
. 2017 Dec;31(4):791-810.
doi: 10.1016/j.idc.2017.07.007. Epub 2017 Sep 13.

Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy

Puja Van Epps  1 , Robert C Kalayjian  2
Affiliations
Review

Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy

Puja Van Epps et al. Infect Dis Clin North Am. 2017 Dec.

Abstract

Persons living with HIV (PLWH) have accentuated risks for age-associated comorbidities. Compared to the general population, PLWH have a 2-fold higher risk of cardiovascular disease, a 3-fold increased risk of fracture, and a risk of kidney disease that is comparable to that in diabetes. Some comorbidities may present at younger ages than among the general population, suggesting the possibility of accelerated aging with HIV infection.

Keywords: Aging; Comorbidities; Frailty; HIV; Senescence; Telomere.

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