Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Aug 29:10:341-345.
doi: 10.2147/CCID.S142819. eCollection 2017.

Psoriasis and vitiligo are close relatives

Khalifa E Sharquie  1 , Husam Ali Salman  1 , Aseel K Yaseen  2
Affiliations

Psoriasis and vitiligo are close relatives

Khalifa E Sharquie et al. Clin Cosmet Investig Dermatol. .

Abstract

Background: Both vitiligo and psoriasis are chronic inflammatory autoimmune diseases with genetic elements.

Objective: To estimate the frequencies of psoriasis in vitiligo patients and vice versa and to compare them with healthy controls.

Patients and methods: A total of 1000 subjects were included, 250 of them had vitiligo, 250 had psoriasis, and 500 were healthy controls. Measurement of the frequencies of vitiligo in psoriatic patients and psoriasis in vitiligo patients was carried out. Thereafter the frequencies of both diseases were assessed in healthy controls. The frequency of vitiligo among psoriatic patients was compared with that of vitiligo in healthy controls. A similar comparison was done between the frequency of psoriasis among vitiligo patients with that in healthy controls. Other comparisons were performed between the frequency of family history of psoriasis among vitiligo patients with that in healthy controls and between the frequency of family history of vitiligo in psoriatic patients with that in healthy controls.

Results: The frequency of psoriasis among vitiligo patients was 15 (6%) and among healthy controls was 2 (0.4%); there is a statistically significant difference (P=0.001). The frequency of vitiligo among psoriatic patients was 5 (2%) and among healthy controls was 3 (0.6%); no statistically significant difference was found (P=0.16). The family history of psoriasis among vitiligo patients was 23 (9.2%) and among healthy controls was 20 (4%); there is a significant association (P=0.043). The family history of vitiligo among psoriatic patients was 24 (9.6%) and among healthy controls was 40 (8%); the difference is statistically significant (P=0.042).

Conclusion: The present work has confirmed the close relationship between vitiligo and psoriasis.

Keywords: overlap; psoriasis; relationship; vitiligo.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Psoriatic lesions superimposed on vitiligo patches and forming advancing border of vitiligo lesion.
Figure 2
Figure 2
Postinflammatory hypopigmentation after resolution of psoriasis.
Figure 3
Figure 3
Leukoderma or vitiligo following healing of psoriasis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Griffiths CEM, Barker JNWN. Psoriasis. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook’s Textbook of Dermatology. 8th ed. Vol. 20. Singapore: Wiley Blackwell Publishing Company; 2010. pp. 871–930.
    1. Wilczek A, Sticherling M. Concomitant psoriasis and bullous pemphigoid: coincidence or pathogenic relationship? Int J Dermatol. 2006;45:1353–1357. - PubMed
    1. Percivalle S, Piccinno R, Caccialanza M. Concurrence of vitiligo and psoriasis: a simple coincidence? Clin Exp Dermatol. 2009;34:90–91. - PubMed
    1. Van de Kerkhof PCM, Schalkwijk J. Psoriasis. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatology. 2nd ed. Vol. 9. Barcelona, Spain: Mosby Elsevier; 2010. pp. 115–135.
    1. Sharquie KE. The Histology and Immunopathology of Vitiligo [PhD thesis] England: University of Sheffield; 1982.

LinkOut - more resources