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Review
. 2017 Dec;35(6):820-826.
doi: 10.1007/s10637-017-0505-5. Epub 2017 Sep 18.

Mechanisms of cancer cell killing by sea cucumber-derived compounds

Teresa Liliana Wargasetia  1 , Widodo  2
Affiliations
Review

Mechanisms of cancer cell killing by sea cucumber-derived compounds

Teresa Liliana Wargasetia et al. Invest New Drugs. 2017 Dec.

Abstract

The aim of cancer therapy is to specifically eradicate tumor cells while causing minimal damage to normal tissues and minimal side-effects. Because of this, the use of natural substances with low toxicity is a good option. Sea cucumbers are one of many potential marine animals that contain valuable nutrients and medicinal properties. The medicinal value of sea cucumbers is attributed to the presence of bioactive agents with promising biological and pharmacological properties that include cytotoxic activity, induction of apoptosis, cell cycle arrest, inhibition of tumor growth, anti-metastatic and anti-angiogenic properties, and inhibition of drug resistance. This review discusses the mechanisms of cancer cell death induced by sea cucumber-derived compounds with regard to exploring the potential use of these marine natural products for cancer therapy.

Keywords: Anti-cancer, apoptosis, metastasis; Sea cucumbers; Triterpene glycosides.

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Conflict of interest statement

Conflict of interest

All authors declare to have no conflict of interest regarding the article.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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