Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jan:78:13-42.
doi: 10.1016/j.metabol.2017.08.010. Epub 2017 Sep 8.

Pharmacotherapy of type 2 diabetes: An update

Jagriti Upadhyay  1 , Stergios A Polyzos  2 , Nikolaos Perakakis  3 , Bindiya Thakkar  4 , Stavroula A Paschou  5 , Niki Katsiki  6 , Patricia Underwood  4 , Kyung-Hee Park  7 , Jochen Seufert  8 , Eun Seok Kang  9 , Elliot Sternthal  4 , Asterios Karagiannis  2 , Christos S Mantzoros  10
Affiliations
Review

Pharmacotherapy of type 2 diabetes: An update

Jagriti Upadhyay et al. Metabolism. 2018 Jan.

Abstract

Type 2 diabetes (T2DM) is a leading cause of morbidity and mortality worldwide and a major economic burden. The prevalence of T2DM is rising, suggesting more effective prevention and treatment strategies are necessary. The aim of this narrative review is to summarize the pharmacologic treatment options available for patients with T2DM. Each therapeutic class is presented in detail, outlining medication effects, side effects, glycemic control, effect on weight, indications and contraindications, and use in selected populations (heart failure, renal insufficiency, obesity and the elderly). We also present representative cost for each antidiabetic category. Then, we provide an individualized guide for initiation and intensification of treatment and discuss the considerations and rationale for an individualized glycemic goal.

Keywords: Algorithm; Goals pharmacotherapy; Personalized therapy; Type 2 diabetes.

PubMed Disclaimer

LinkOut - more resources