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. 2017 Oct 1;76(10):838-847.
doi: 10.1093/jnen/nlx076.

A Rationale for Targeting Extracellular Regulated Kinases ERK1 and ERK2 in Glioblastoma

Ricarda Hannen  1 , Maria Hauswald  1 , Joerg Walter Bartsch  1
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A Rationale for Targeting Extracellular Regulated Kinases ERK1 and ERK2 in Glioblastoma

Ricarda Hannen et al. J Neuropathol Exp Neurol. .

Abstract

Glioblastoma (GBM) is the most common malignant primary brain tumor. It still carries a grim prognosis and new therapies are needed. This review summarizes the current status of mechanistic insights into the function of extracellular regulated kinase (ERK) and its potential as a therapeutic target for patients with GBM. Currently, some promising ERK inhibitors are in clinical trials in tumor entities other than GBM. Here, we provide a comprehensive overview on the functions of ERK1/2 in GBM and a rationale for treatment of GBM with ERK inhibitors.

Keywords: ERK inhibitors; Extracellular regulated kinase; Glioblastoma.

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