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Comment
. 2017 Nov;33(11):831-832.
doi: 10.1016/j.pt.2017.08.007. Epub 2017 Sep 8.

Malaria Parasites in a Hungry Host: Kinases and Host Caloric Restriction Brought Together

Jose F Garcia-Bustos  1 , Christian Doerig  2
Affiliations
Comment

Malaria Parasites in a Hungry Host: Kinases and Host Caloric Restriction Brought Together

Jose F Garcia-Bustos et al. Trends Parasitol. 2017 Nov.

Abstract

A study recently published in Nature links reduced calorie nutritional intake of host mice with (i) reduced severity of cerebral malaria, (ii) decreased parasitemia, and (iii) activation of a nutrient-sensing pathway that regulates the parasite's proliferation rate. Here, we discuss these findings in the context of human malaria pathology and Plasmodium kinomics.

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  • Nutrient sensing modulates malaria parasite virulence.
    Mancio-Silva L, Slavic K, Grilo Ruivo MT, Grosso AR, Modrzynska KK, Vera IM, Sales-Dias J, Gomes AR, MacPherson CR, Crozet P, Adamo M, Baena-Gonzalez E, Tewari R, Llinás M, Billker O, Mota MM. Mancio-Silva L, et al. Nature. 2017 Jul 13;547(7662):213-216. doi: 10.1038/nature23009. Epub 2017 Jul 5. Nature. 2017. PMID: 28678779 Free PMC article.

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