Rethinking End Points in Clinical Trials of Renoprotective Medication
- PMID: 28923832
- PMCID: PMC5628724
- DOI: 10.2215/CJN.09040817
Rethinking End Points in Clinical Trials of Renoprotective Medication
Keywords: Clinical Trials; Endpoint Determination; Renoprotective Medication.
Comment on
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Is Chronic Dialysis the Right Hard Renal End Point To Evaluate Renoprotective Drug Effects?Clin J Am Soc Nephrol. 2017 Oct 6;12(10):1595-1600. doi: 10.2215/CJN.09590916. Epub 2017 Sep 18. Clin J Am Soc Nephrol. 2017. PMID: 28923834 Free PMC article.
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- Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving H, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S: Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345: 861–869, 2001 - PubMed
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- Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Lewis JB, Ritz E, Atkins RC, Rohde R, Raz I: Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 345: 851–860, 2001 - PubMed
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- Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int 3(Suppl): 1–150, 2013.
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