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. 1988 Jan;42(1):38-44.

Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene

G M Lathrop  1 , M Farrall, P O'Connell, B Wainwright, M Leppert, Y Nakamura, N Lench, H Kruyer, M Dean, M Park, et al.
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Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene

G M Lathrop et al. Am J Hum Genet. 1988 Jan.

Abstract

The genetic map in the region of human chromosome 7 that harbors the gene for cystic fibrosis (CF) has been refined by multilocus linkage studies in an expanded database including a large set of normal families. Six loci known to be linked to CF were examined: MET, an oncogene; COL1A2, collagen, TCRB, T-cell-receptor beta polypeptide; and three arbitrary loci--D7S8, D7S13, and D7S16--defined by probes pJ3.11, pB79a, and p7C22, respectively. The gene order with greatest statistical support is COL1A2-D7S13-D7S16-MET-D7S8-TCRB. Linkage analysis in families segregating for CF suggested that the most likely location of the CF gene on this map is between MET and D7S8.

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