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Comment
. 2017 Oct;27(10):1187-1188.
doi: 10.1038/cr.2017.120. Epub 2017 Sep 19.

Size matters: Finding growth pathways that protect the heart

J Sawalla Guseh  1 , Anthony Rosenzweig  1
Affiliations
Comment

Size matters: Finding growth pathways that protect the heart

J Sawalla Guseh et al. Cell Res. 2017 Oct.

Abstract

In a recent paper published in Cell Research, Abdul-Ghani and colleagues show that the cytokine, cardiotrophin-1 (CT1), drives a protective form of reversible cardiac hypertrophy that acts through a nonapoptotic caspase-dependent mechanism. Since CT1 can be delivered as exogenous protein, these studies provide new biological insights and potential translational opportunities.

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Figures

Figure 1
Figure 1
Exogenous CT1 induces caspase-dependent cardiac hypertrophy. CK2 limits caspase activation, which may prevent development of irreversible pathological hypertrophy.
See this image and copyright information in PMC

Comment on

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