Autoantibody to proliferating cell nuclear antigen (PCNA) in SLE: a clinical and serological study
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Autoantibody to proliferating cell nuclear antigen (PCNA) in SLE: a clinical and serological study
Clin Exp Rheumatol.
1987 Jul-Sep.
Abstract
In a clinical and serological follow-up study on a large series of subjects with different connective tissue disorders, anti-PCNA/cyclin autoantibodies were found in about 3% of patients with SLE. Positive subjects showed a higher incidence of diffuse proliferative glomerulonephritis and hematological disorders than the general SLE population. A highly significant serological association between PCNA and SL/Ki autoantibodies (p less than 0.001) has been observed. Persistence or disappearance of serum PCNA antibodies were independent of any clinical and serological feature or the therapeutic regimen employed.
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