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. 1987 Dec;78(12):1415-9.

Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells

T Tsuruo  1 , Y Sugimoto, H Hamada, I Roninson, M Okumura, K Adachi, Y Morishima, R Ohno
Affiliations
  • PMID: 2892823

Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells

T Tsuruo et al. Jpn J Cancer Res. 1987 Dec.

Abstract

We have examined the expression of P-glycoprotein in clinical leukemic cell samples by using a monoclonal antibody (MRK16) against P-glycoprotein. We found that leukemia cells isolated from 3 out of 6 patients with blast crisis of chronic myelogenous leukemia were reactive to MRK16. These 3 cell lines expressed high levels of mdr1 mRNA, which codes for P-glycoprotein. The present result indicates that the clinically refractory state of the tumor may be predicted in part by determining P-glycoprotein expression using the monoclonal antibody against P-glycoprotein, and the mdr1 probe.

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