Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Jul-Sep;11(3):797-801.
doi: 10.4103/0259-1162.194554.

Anesthesia Management of a Child with Osteopetrosis

Hashem Jarineshin  1 , Fereydoon Fekrat  1 , Mehdi Feiz Dowlat Abadi  1
Affiliations
Case Reports

Anesthesia Management of a Child with Osteopetrosis

Hashem Jarineshin et al. Anesth Essays Res. 2017 Jul-Sep.

Abstract

Osteopetrosis is a rare genetic disorder of osteoclast dysfunction leading to anatomical and physiological disorders. We present the anesthesia management for the femur fracture of a 4-year-old girl with malignant infantile type of osteopetrosis. She had a ventriculoperitoneal shunt, impaired motion, visual disturbance, growth failure, facial deformity, heart murmur of moderate tricuspid regurgitation, and left ventricular heart failure, with splenomegaly and severe anemia.

Keywords: Airway management; bone fracture; osteopetrosis.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
A 4-year-old girl with femur fracture due to osteopetrosis-related osteosclerotic bone changes
Figure 2
Figure 2
Facial appearance with lower hyperplasic jaw, restricted temporomandibular joint, obliterated nasal passage, mandibular abnormalities with hypoplasia, macrocephaly, and hypertelorism
Figure 3
Figure 3
Bone changes and pathological fractures along with failure to thrive, anemia, thrombocytopenia, hepatosplenomegaly, and extramedullary hematopoiesis
See this image and copyright information in PMC

References

    1. Rajathi M, Austin R, Mathew P, Bharathi C, Srivastava K. Autosomal-dominant osteopetrosis: An incidental finding. Indian J Dent Res. 2010;21:611. - PubMed
    1. Ozer AB, Erhan OL, Demirel I, Ozcan S. Administration of general anaesthesia to a paediatric patient with osteopetrosis. BMJ Case Rep 2012. 2012 - PMC - PubMed
    1. Kant P, Sharda N, Bhowate RR. Clinical and radiological findings of autosomal dominant osteopetrosis Type II: A Case Report. Case Rep Dent 2013. 2013:707343. - PMC - PubMed
    1. Burt N, Haynes GR, Bailey MK. Patients with malignant osteopetrosis are at high risk of anesthetic morbidity and mortality. Anesth Analg. 1999;88:1292–7. - PubMed
    1. Carter M, Stokes D, Wang W. Severe obstructive sleep apnea in a child with osteopetrosis. Clin Pediatr (Phila) 1988;27:108–10. - PubMed

Publication types