Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Sep;14(3):2598-2602.
doi: 10.3892/ol.2017.6490. Epub 2017 Jun 28.

Importance of tuberin in carcinogenesis

Mingwei Jin  1 , Qi An  1 , Lei Wang  1
Affiliations

Importance of tuberin in carcinogenesis

Mingwei Jin et al. Oncol Lett. 2017 Sep.

Abstract

The cell cycle is a dynamic process with multiple phases regulating cell growth. The proper regulation is essential for avoiding errors and activation of cell death. Tumour suppressor proteins, including tuberin, are crucial in coordinating adequate cell growth and properly timed cell division. So, the present review article is focused on the latest aspects of the tuberin in the process of carcinogenesis. The PubMed was the main database used for the collection of latest data relating to multiple aspects of tuberin especially in context of cancer. Most of the recent studies revealed that mutation, truncation, and deregulation of the tuberin protein could definitely lead to cancer. Recent studies are also devoted to explore implications towards better understanding the progression of disease involving mis-regulated tuberin.

Keywords: cancer; cell cycle; tuberin.

PubMed Disclaimer

References

    1. Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB. A pleiotropic RNA-binding protein controls distinct cell cycle checkpoints to drive resistance of p53-defective tumors to chemotherapy. Cancer Cell. 2015;28:623–637. doi: 10.1016/j.ccell.2015.09.009. - DOI - PMC - PubMed
    1. Badjatia N, Park SH, Ambrósio DL, Kirkham JK, Günzl A. Cyclin-dependent kinase CRK9, required for spliced leader trans splicing of pre-mRNA in trypanosomes, functions in a complex with a new L-type cyclin and a kinetoplastid-specific protein. PLoS Pathog. 2016;12:e1005498. doi: 10.1371/journal.ppat.1005498. - DOI - PMC - PubMed
    1. Gaggioli V, Zeiser E, Rivers D, Bradshaw CR, Ahringer J, Zegerman P. CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans. J Cell Biol. 2014;204:507–522. doi: 10.1083/jcb.20131008303042014c. - DOI - PMC - PubMed
    1. Vermeulen K, Van Bockstaele DR, Berneman ZN. The cell cycle: A review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif. 2003;36:131–149. doi: 10.1046/j.1365-2184.2003.00266.x. - DOI - PMC - PubMed
    1. Nurse PM. Nobel lecture. Cyclin dependent kinases and cell cycle control. Biosci Rep. 2002;22:487–499. doi: 10.1023/A:1022017701871. - DOI - PubMed