Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov;34(11):1640-1648.
doi: 10.1111/echo.13675. Epub 2017 Sep 19.

Correlation between myocardial deformation on three-dimensional speckle tracking echocardiography and cardiopulmonary exercise testing

Mei Li  1 , Yaran Lu  1 , Cui Fang  1 , Xiaorong Zhang  1
Affiliations

Correlation between myocardial deformation on three-dimensional speckle tracking echocardiography and cardiopulmonary exercise testing

Mei Li et al. Echocardiography. 2017 Nov.

Abstract

Purpose: Heart failure (HF) is a multifactorial entity that combines derangements in both systolic and diastolic function. The relationship between systolic and diastolic function and exercise capacity is not fully understood. We sought to determine the mechanisms linking cardiac function and exercise tolerance in patients with HF.

Methods: One hundred fifty-six subjects with different cardiac function levels were included in the study. Subjects' 2D echocardiographic, 3D speckle tracking echocardiographic, and cardiopulmonary exercise testing (CPET) data were collected.

Result: The amount of untwisting at 25% of the untwist duration (25%Untwist) and global longitudinal peak systolic strain (GLS) showed the best positive correlations with peak oxygen uptake (peakVO2 ) (r = .41; P < .001 and r = .32; P < .001, respectively), while the left ventricular ejection fraction (EF) was weakly correlated with peakVO2 . The 25%Untwist value was negatively correlated with the carbon dioxide equivalent slope (VE/VCO2 ) (r = -.49; P < .001). Both E/e and the left atrium volume index (LA index) exhibited good positive correlations with VE/VCO2 (r = .39; P < .01 and r = .32; P < .001). In the multiple regression analysis, the best predictive model for the peakVO2 included the 25%Untwist, GLS, and E/e, explained 64% of the variation in peakVO2 , with 25%Untwist explaining 17.6% of the variation. Including EF in the model explained only 3.1% of the variation in peakVO2 . In a multivariable model for VE/VCO2 , 25%Untwist was the strongest independent predictor, explaining 23% of the variance in VE/VCO2 .

Conclusion: Left ventricular early diastolic function is a modest independent predictor of aerobic exercise capacity. The 25%Untwist value is a good indicator of cardiac diastolic function.

Keywords: cardiopulmonary exercise testing; diastolic dysfunction; echocardiography; heart failure; three-dimensional speckle tracking.

PubMed Disclaimer

LinkOut - more resources