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. 2017 Oct;23(10):1657-1663.
doi: 10.3201/eid2310.170488.

Antimicrobial Drug Prescription and Neisseria gonorrhoeae Susceptibility, United States, 2005-2013

Robert D Kirkcaldy, Monina G Bartoces, Olusegun O Soge, Stefan Riedel, Grace Kubin, Carlos Del Rio, John R Papp, Edward W Hook 3rd, Lauri A Hicks

Antimicrobial Drug Prescription and Neisseria gonorrhoeae Susceptibility, United States, 2005-2013

Robert D Kirkcaldy et al. Emerg Infect Dis. 2017 Oct.

Abstract

We investigated whether outpatient antimicrobial drug prescribing is associated with Neisseria gonorrhoeae antimicrobial drug susceptibility in the United States. Using susceptibility data from the Gonococcal Isolate Surveillance Project during 2005-2013 and QuintilesIMS data on outpatient cephalosporin, macrolide, and fluoroquinolone prescribing, we constructed multivariable linear mixed models for each antimicrobial agent with 1-year lagged annual prescribing per 1,000 persons as the exposure and geometric mean MIC as the outcome of interest. Multivariable models did not demonstrate associations between antimicrobial drug prescribing and N. gonorrhoeae susceptibility for any of the studied antimicrobial drugs during 2005-2013. Elucidation of epidemiologic factors contributing to resistance, including further investigation of the potential role of antimicrobial drug use, is needed.

Keywords: Neisseria gonorrhoeae; United States; antibacterial agents; antimicrobial drug; bacterial; drug resistance; drug susceptibility; gonorrhea; utilization.

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