Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep 12;3(3):24.
doi: 10.3390/medicines3030024.

Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis

Ashutosh Pathak  1 , Dalip Kumar Upreti  2 , Anupam Dikshit  3
Affiliations

Antidermatophytic Activity of the Fruticose Lichen Usnea orientalis

Ashutosh Pathak et al. Medicines (Basel). .

Abstract

In the present study, the new biological sources in the form of lichen Usnea orientalis Motyka was screened for its antidermatophytic potential. Six species of dermatophytes were chosen on the basis of their prevalence for antidermatophytic assays, and the Clinical Laboratory Standard Institute (CLSI)-recommended broth microdilution procedure was used to detect the efficacy of extract against dermatophytes. Thin layer chromatography of lichen extracts reveals the presence of two secondary metabolites viz. salazinic acid and usnic acid. U. orientalis extract exhibited promising antidermatophytic activity against all tested pathogens. Amongst all tested pathogens, Epidermophyton floccosum exhibited most susceptibility towards extract, whereas Trichophyton mentagrophytes exhibited the least susceptibility. Topical application of U. orientalis extract might be helpful in the cure of dermal infections.

Keywords: DPPH; Lichen; antidermatophytic; dermatophytes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Antidermatophytic activity U. orientalis extract compared with Sertaconazole nitrate. Error bars show the standard error mean. ** Level of significance ≤ 0.01. * Level of significance ≤ 0.05.
See this image and copyright information in PMC

References

    1. Hawksworth D.L. Freshwater and marine lichen-forming. In: Hyde K.D., Ho W.H., Pointing S.B., editors. Aquatic Mycology across the Millennium. Volume 5 Fungal Diversity; Hong Kong, China: 2000.
    1. Molnar K., Farkas E. Current results on Biological Activities of Lichen Secondary Metabolites: A Review. Z. Naturforschung C. 2010;65:157–173. doi: 10.1515/znc-2010-3-401. - DOI - PubMed
    1. Shukla P., Upreti D.K., Tewari L.M. Secondary metabolite variability in genus Usnea in India: A potential source for bioprospection. J. Environ. Sci. Technol. 2015;2:44–55.
    1. Wang L.S., Qian Z.G. Pictorial Handbook to Medicinal Lichens in Chin. Yunnan Provincial Science and Technology Publishers; Kunming, China: 2013.
    1. Dias M.F.R.G., Quaresma-Santos M.V.P., Bernardes-Filho F., Amorim A.G.F., Schechtman R.C., Azulay D.R. Update on therapy for superficial mycoses: Review article part 1. An. Bras. Dermatol. 2013;88:764–774. doi: 10.1590/abd1806-4841.20131996. - DOI - PMC - PubMed

LinkOut - more resources