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Comment
. 2017 Oct 10;56(40):5221-5222.
doi: 10.1021/acs.biochem.7b00702. Epub 2017 Sep 20.

Cation-π Lights Up "Halo"

Jianmin Gao  1
Affiliations
Comment

Cation-π Lights Up "Halo"

Jianmin Gao. Biochemistry. .

Abstract

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Figures

Figure 1.
Figure 1.
Fluorogenic reporters of HaloTag. a) An example of rhodamine-based fluorescence reporter that acquires fluorescence via spirolactone isomerization; b) Fluorogenic reporters developed by Kool and coworkers based on molecular rotors; c) A solvatochromic dye-based reporter (P9) of HaloTag developed by Zhang and coworkers; d) Fluorescence emission of P9 in absence and presence of HaloTag showing 1,000 fold fluorescence increase; only marginal fluorescence was observed with the non-reactive D106A mutant; e) Mechanistic views of the P9 fluorogenicity highlighting the importance of a cation-π interaction.
See this image and copyright information in PMC

Comment on

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