Take DAT, Flu!

Lior Lobel¹, Wendy S Garrett²

Affiliations

¹ Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
² Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department and Division of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA. Electronic address: wgarrett@hsph.harvard.edu.

PMID: 28930655
DOI: 10.1016/j.immuni.2017.09.002

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Take DAT, Flu!

Lior Lobel et al. Immunity. 2017.

Free article

. 2017 Sep 19;47(3):400-402.

doi: 10.1016/j.immuni.2017.09.002.

Authors

Lior Lobel¹, Wendy S Garrett²

Affiliations

¹ Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
² Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department and Division of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA. Electronic address: wgarrett@hsph.harvard.edu.

PMID: 28930655
DOI: 10.1016/j.immuni.2017.09.002

Abstract

Some microbial metabolites can be immunomodulatory, but there is limited understanding of how these contribute to inter-individual variation in response to infection. In a recent study in Science, Steed et al. (2017) show that the bacterial metabolite desaminotyrosine (DAT) increases type I interferon expression, resulting in an improved immune response to influenza infection.

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The microbial metabolite desaminotyrosine protects from influenza through type I interferon.
Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS. Steed AL, et al. Science. 2017 Aug 4;357(6350):498-502. doi: 10.1126/science.aam5336. Science. 2017. PMID: 28774928 Free PMC article.

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Take DAT, Flu!

Affiliations

Take DAT, Flu!

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Publication types

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Medical