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Meta-Analysis
. 2017 Sep;96(38):e8014.
doi: 10.1097/MD.0000000000008014.

The prognostic value of shock index for the outcomes of acute myocardial infarction patients: A systematic review and meta-analysis

Xiaocong Zhang  1 , Zejie Wang, Zhenyu Wang, Manling Fang, Zhouwu Shu
Affiliations
Meta-Analysis

The prognostic value of shock index for the outcomes of acute myocardial infarction patients: A systematic review and meta-analysis

Xiaocong Zhang et al. Medicine (Baltimore). 2017 Sep.

Abstract

Background: Several studies have revealed that high shock index (SI) is a risk factor for acute myocardial infarction (AMI) patients. These studies do not give a systematic review in this issue. Therefore, we conducted a systematic review and meta-analysis to determine the effect of high SI on the prognosis of AMI patients.

Methods: We did a systematic search of PubMed, Embase, and the Cochrane Library, using various combinations of keywords such as "shock index," "shock-index," "acute myocardial infarction," "ST elevation myocardial infarction," "non-ST segment elevation myocardial infarction," "STEMI," "NSTEMI," "AMI," and "MI" for eligible studies published up to December 23, 2016. The 3 primary outcomes for this analysis were all-cause in-hospital mortality, short-term adverse outcomes, and long-term adverse outcomes.

Results: Database searches retrieved 226 citations. Finally, 8 studies enrolling 20,404 patients were eventually included in the analysis. High SI was associated with an increased in-hospital mortality (pooled RR = 10.96, 95% CI: 2.00-59.94, P = .01). Adverse outcomes were significantly higher in the high SI group compared to the low SI group (pooled RR = 1.93, 95% CI: 1.10-3.39, P = .02; I = 95%). Individuals with high SI had an increased risk of long-term adverse outcomes (pooled RR = 2.31, 95% CI: 1.90-2.81, P < .001) compared to low SI.

Conclusion: High SI may increase the in-hospital mortality, short-term, and long-term adverse outcomes in AMI patients.

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Conflict of interest statement

The authors declare that they have no conflicts of interests.

Figures

Figure 1
Figure 1
Flow of chart.
Figure 2
Figure 2
The relationship between in-hospital mortality and high SI. SI = shock index.
Figure 3
Figure 3
The relationship between short-term adverse outcomes and high SI. SI = shock index.
Figure 4
Figure 4
The relationship between long-term adverse outcomes and high SI. SI = shock index.
Figure 5
Figure 5
The funnel plots showed each comparison outcomes.
See this image and copyright information in PMC

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