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Case Reports
. 2017 Sep 20;10(1):490.
doi: 10.1186/s13104-017-2746-y.

Sentinel lymph node biopsy in periocular merkel cell carcinoma: a case report

Dan C Filitis  1 , Gyorgy Paragh  2 , Faramarz H Samie  3   4 , Nathalie C Zeitouni  5
Affiliations
Case Reports

Sentinel lymph node biopsy in periocular merkel cell carcinoma: a case report

Dan C Filitis et al. BMC Res Notes. .

Abstract

Background: The National Comprehensive Cancer Network guidelines for Merkel cell carcinoma recommend performance of the sentinel lymph node biopsy in all patients with clinically negative nodal disease for staging and treatment. Nevertheless, sentinel lymph node biopsy in the periocular region is debated as tumors are typically smaller and lymphatic variability can make performance procedurally problematic.

Case presentation: We present a case of a Caucasian patient in their seventies who presented with a 1.0 cm periocular Merkel cell carcinoma, who underwent Mohs surgery with a Tenzel flap repair, that was found to have a positive sentinel lymph node biopsy, but who, despite parotidectomy, selective neck dissection, and radiation, succumbed to the disease.

Conclusions: Evidence in both the site-specific and non-specific literature demonstrates: (1) Worsening prognosis with extent of lymph node burden, (2) improvements in our abilities to perform lymphoscintigraphy, (3) locoregional and distant metastatic disease in patients with tumor sizes ≤1 cm, and (4) significant rates of sentinel lymph node positivity in patients with tumor sizes ≤1 cm. Our case supports that sentinel lymph node biopsy should be considered in all clinically nodal negative periocular Merkel cell carcinoma, regardless of size, and despite limited site-specific studies on the subject.

Keywords: Case report; Merkel cell carcinoma; Periocular; Sentinel lymph node biopsy.

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