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Review
. 2018 Jan 1;314(1):F1-F8.
doi: 10.1152/ajprenal.00263.2017. Epub 2017 Sep 20.

PGC1α in the kidney

Matthew R Lynch  1 , Mei T Tran  1 , Samir M Parikh  1
Affiliations
Review

PGC1α in the kidney

Matthew R Lynch et al. Am J Physiol Renal Physiol. .

Abstract

Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a master regulator of mitochondrial biogenesis, has been shown to be protective in AKI. Interestingly, reduction of PGC1α has also been implicated in the development of diabetic kidney disease and renal fibrosis. The beneficial renal effects of PGC1α make it a prime target for therapeutics aimed at ameliorating AKI, forms of chronic kidney disease (CKD), and their intersection. This review summarizes the current literature on the relationship between renal health and PGC1α and proposes areas of future interest.

Keywords: AKI; CKD; PGC1α; kidney; metabolism.

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Figures

Fig. 1.
Fig. 1.
PGC1α and key modulators. AMP kinase, Sirtuin enzymes, and PGC1α comprise a circuit that senses and responds to stressors that affect energy metabolism. Depicted are biological and chemical modulators of this circuit that have been implicated in renal studies of PGC1α as described in the text. Arrows indicate positive interactions. “T” arrows indicate inhibitory interactions.
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