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Review
. 2017 May-Aug;21(2):260-263.
doi: 10.4103/jomfp.JOMFP_143_17.

Current concepts of pemphigus with a deep insight into its molecular aspects

Jayakiran Madala  1 , Rithika Bashamalla  1 , M Praveen Kumar  1
Affiliations
Review

Current concepts of pemphigus with a deep insight into its molecular aspects

Jayakiran Madala et al. J Oral Maxillofac Pathol. 2017 May-Aug.

Abstract

Pemphigus vulgaris is an autoimmune bullous disease involving both the skin and mucosal areas, which is characterized by intraepithelial flaccid blisters and erosions. The pathogenesis of this disease is not yet completely established, but novel intuitions into its pathogenesis have recently been published. An unanswered question in its pathophysiology is the mechanism of acantholysis or loss of keratinocyte cell adhesion. Acantholysis seems to result from a communal action of autoantibodies against numerous keratinocyte self-antigens, of which desmogleins 1 and 3, desmocollins and nondesmosome components, such as the mitochondrion, might take part in the disease initiation. Lately, apoptosis was described as a possible underlying mechanism of acantholysis. Likewise, apoptolysis is assumed to be the association between suprabasal acantholytic and cell death pathways. Hence, the present review focuses on the current concepts in the pathogenesis of the pemphigus in a nutshell.

Keywords: Acantholysis; apoptolysis; apoptosis.

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Conflict of interest statement

There are no conflicts of interest.

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