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Review
. 2017:2017:2452853.
doi: 10.1155/2017/2452853. Epub 2017 Aug 27.

Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM

Marwan A Ahmed  1 , George L Muntingh  1 , Paul Rheeder  2
Affiliations
Review

Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM

Marwan A Ahmed et al. Int J Endocrinol. 2017.

Abstract

Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies.

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References

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