Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul 31:11:252-261.
doi: 10.2174/1874364101711010252. eCollection 2017.

Pathophysiology of Keratoconus: What Do We Know Today

Uri Soiberman  1 , James W Foster  1 , Albert S Jun  1 , Shukti Chakravarti  1
Affiliations

Pathophysiology of Keratoconus: What Do We Know Today

Uri Soiberman et al. Open Ophthalmol J. .

Abstract

Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.

Keywords: Corneal epithelium; Cytokine; Keratoconus; Keratocytes; Morphology; Oxidative stress; Pathogenesis; Proteomics; TGF-β.

PubMed Disclaimer

References

    1. Klintworth G.K., Damms T. Corneal dystrophies and keratoconus. Curr. Opin. Ophthalmol. 1995;6(4):44–56. doi: 10.1097/00055735-199508000-00009. - DOI - PubMed
    1. Rabinowitz Y.S. Keratoconus. Surv. Ophthalmol. 1998;42(4):297–319. doi: 10.1016/S0039-6257(97)00119-7. - DOI - PubMed
    1. Rahi A., Davies P., Ruben M., Lobascher D., Menon J. Keratoconus and coexisting atopic disease. Br. J. Ophthalmol. 1977;61(12):761–764. doi: 10.1136/bjo.61.12.761. - DOI - PMC - PubMed
    1. Lu Y., Vitart V., Burdon K.P., Khor C.C., Bykhovskaya Y., Mirshahi A., Hewitt A.W., Koehn D., Hysi P.G., Ramdas W.D., Zeller T., Vithana E.N., Cornes B.K., Tay W.T., Tai E.S., Cheng C.Y., Liu J., Foo J.N., Saw S.M., Thorleifsson G., Stefansson K., Dimasi D.P., Mills R.A., Mountain J., Ang W., Hoehn R., Verhoeven V.J., Grus F., Wolfs R., Castagne R., Lackner K.J., Springelkamp H., Yang J., Jonasson F., Leung D.Y., Chen L.J., Tham C.C., Rudan I., Vatavuk Z., Hayward C., Gibson J., Cree A.J., MacLeod A., Ennis S., Polasek O., Campbell H., Wilson J.F., Viswanathan A.C., Fleck B., Li X., Siscovick D., Taylor K.D., Rotter J.I., Yazar S., Ulmer M., Li J., Yaspan B.L., Ozel A.B., Richards J.E., Moroi S.E., Haines J.L., Kang J.H., Pasquale L.R., Allingham R.R., Ashley-Koch A., Mitchell P., Wang J.J., Wright A.F., Pennell C., Spector T.D., Young T.L., Klaver C.C., Martin N.G., Montgomery G.W., Anderson M.G., Aung T., Willoughby C.E., Wiggs J.L., Pang C.P., Thorsteinsdottir U., Lotery A.J., Hammond C.J., van Duijn C.M., Hauser M.A., Rabinowitz Y.S., Pfeiffer N., Mackey D.A., Craig J.E., Macgregor S., Wong T.Y., NEIGHBOR Consortium Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat. Genet. 2013;45(2):155–163. doi: 10.1038/ng.2506. - DOI - PMC - PubMed
    1. Hameedaldeen A., Liu J., Batres A., Graves G.S., Graves D.T. FOXO1, TGF-β regulation and wound healing. Int. J. Mol. Sci. 2014;15(9):16257–16269. doi: 10.3390/ijms150916257. - DOI - PMC - PubMed

LinkOut - more resources