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Review
. 2017 Aug 26;9(8):667-672.
doi: 10.4330/wjc.v9.i8.667.

Is there evidence for statins in the treatment of aortic valve stenosis?

Ibrahim Akin  1 , Christoph A Nienaber  2
Affiliations
Review

Is there evidence for statins in the treatment of aortic valve stenosis?

Ibrahim Akin et al. World J Cardiol. .

Abstract

Research revealed that the pathogenesis of aortic stenosis (AS) not merely comprises of a mechanical wear and tear process yet that active biological processes, similar to those of coronary artery disease are involved, a promising role for statins in disease-modifying therapy was suggested. However, recently, many prospective studies could not observe decreased progression nor regression of the disease. Here, we review the current knowledge on the pathomechanisms of AS and its similarities and differences with atherosclerosis. Moreover, we discuss whether there is still a place for statins in the treatment of particular AS patient subgroups.

Keywords: Aortic stenosis; Aortic valve surgery; Coronary artery stenosis; HMG-CoA enzyme inhibitor; Statins.

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Conflict of interest statement

Conflict-of-interest statement: No conflict of interest for all authors.

Figures

Figure 1
Figure 1
Schematic overview of statin effects on aortic valve calcification.
See this image and copyright information in PMC

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