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. 2017 Mar;9(1):9-14.
doi: 10.1556/1646.9.2017.1.05.

Prolonged QRS duration on surface electrocardiogram is associated with left ventricular restrictive filling pattern

Turan Erdoğan  1   2 , Murtaza Emre Durakoğlugil  1 , Yüksel Çiçek  1 , Mustafa Çetin  1 , Hakan Duman  1 , Ömer Şatiroğlu  1 , Şükrü Çelik  2   3
Affiliations

Prolonged QRS duration on surface electrocardiogram is associated with left ventricular restrictive filling pattern

Turan Erdoğan et al. Interv Med Appl Sci. 2017 Mar.

Abstract

Background: Prolonged QRS duration is associated with decreased left ventricular (LV) systolic function. However, the relation between LV restrictive filling pattern (RFP) and QRS duration has not been investigated yet. The purpose of our study was to assess this relationship.

Methods: We analyzed standard 12-lead surface electrocardiogram (ECG) of 155 consecutive patients. Mitral inflow and septal tissue velocities were obtained using the apical 4-chamber view with pulsed Doppler echocardiography. Patients were divided into 2 groups according to measured deceleration time (DT): restrictive (with DT ≤130 ms) or non-restrictive (with DT >130 ms).

Results: QRS duration was significantly longer in the restrictive group than in the non-restrictive group (0.101 vs. 0.090 s, p < 0.0001). QRS duration of >0.10 s was highly specific (82.6%), but modestly sensitive (64.7%), for the prediction of LV RFP. Multivariate analyses demonstrated that E/A ratio, peak E, peak A, septal e', and a' velocities were significantly associated with RFP.

Conclusions: Prolonged QRS duration (>0.10 s) obtained from a standard resting 12-lead ECG is associated with LV RFP. However, the relationship of QRS duration with RFP was not independent of echocardiographic parameters.

Keywords: QRS duration; deceleration time; electrocardiography; restrictive filling pattern; tissue Doppler.

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Figures

Fig. 1.
Fig. 1.
Distribution of a prolonged QRS duration based on restrictive or non-restrictive filling pattern
See this image and copyright information in PMC

References

    1. O’Keefe JH, Zinsmeister AR, Gibbons RJ: Value of normal electrocardiographic findings in predicting resting left ventricular function in patients with chest pain and suspected coronary artery disease. Am J Med 86, 658–662 (1989) - PubMed
    1. Rihal CS, Davis KB, Kennedy JW, Gersh BJ: The utility of clinical, electrocardiographic, and roentgenographic variables in the prediction of left ventricular function. Am J Cardiol 75, 220–223 (1995) - PubMed
    1. Christian TF, Chareonthaitawee P, Miller TD, Hodge DO, Gibbons RJ: Is it necessary to measure resting left ventricular function in patients with normal resting electrocardiograms? Circulation 94, 11–20 (1996)
    1. Christian TF, Miller TD, Chareonthaitawee P, Hodge DO, O’Connor MK, Gibbons RJ: Prevalence of normal resting left ventricular function with normal rest electrocardiograms. Am J Cardiol 79, 1295–1298 (1997) - PubMed
    1. Murkofsky RL, Dangas G, Diamond JA, Mehta D, Schaffer A, Ambrose JA: A prolonged QRS duration on surface electrocardiogram is a specific indicator of left ventricular dysfunction. J Am Coll Cardiol 32, 476–482 (1998) - PubMed

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