Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Aug;9(8):2264-2267.
doi: 10.21037/jtd.2017.07.43.

Heart-resident macrophages: are they involved in the rhythm of every beat?

Emanuel Harari  1 , Liang Guo  1 , Samantha L Smith  1 , Ryan E Braumann  1 , Renu Virmani  1 , Aloke V Finn  1   2
Affiliations
Editorial

Heart-resident macrophages: are they involved in the rhythm of every beat?

Emanuel Harari et al. J Thorac Dis. 2017 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Histology of human pathological compact atrioventricular node and immunofluorescence staining. A 27-year-old male who died of sudden cardiac arrest, and histology of conduction system showed fragmentation of compact atrioventricular node with possible nodoventricular accessory conduction pathway. (A,B) Movat pentachrome staining; (C,D) immunofluorescence staining of macrophage marker CD68 (green), and connexin 43 (red); (B) and (C) are matched area from Movat pentachrome staining and immunofluorescence; (C) high power image from boxed area in panel (B); (D) arrows are pointing to the AV node macrophages, high-resolution confocal microscope image showing one spindle-shaped macrophage in the vicinity of a cardiomyocyte fiber with positive connexin 43 staining. AV, atrioventricular.
See this image and copyright information in PMC

Comment on

  • Macrophages Facilitate Electrical Conduction in the Heart.
    Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. Hulsmans M, et al. Cell. 2017 Apr 20;169(3):510-522.e20. doi: 10.1016/j.cell.2017.03.050. Cell. 2017. PMID: 28431249 Free PMC article.

References

    1. Moore KJ, Sheedy FJ, Fisher EA. Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol 2013;13:709-21. 10.1038/nri3520 - DOI - PMC - PubMed
    1. van Dijk RA, Rijs K, Wezel A, et al. Systematic Evaluation of the Cellular Innate Immune Response During the Process of Human Atherosclerosis. J Am Heart Assoc 2016;5. - PMC - PubMed
    1. Italiani P, Boraschi D. From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation. Front Immunol 2014;5:514. 10.3389/fimmu.2014.00514 - DOI - PMC - PubMed
    1. Dutta P, Nahrendorf M. Monocytes in myocardial infarction. Arterioscler Thromb Vasc Biol 2015;35:1066-70. 10.1161/ATVBAHA.114.304652 - DOI - PMC - PubMed
    1. Nahrendorf M, Swirski FK, Aikawa E, et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007;204:3037-47. 10.1084/jem.20070885 - DOI - PMC - PubMed

LinkOut - more resources