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Case Reports
. 2017 Sep 13:4:e108.
doi: 10.14309/crj.2017.108. eCollection 2017.

Extraosseous Calcification of the Esophagus: Clinicopathologic Correlates of Esophageal Mucosal Calcinosis

Ari Garber  1 , Zubin Arora  1 , Nicole Welch  1 , James Lapinski  2 , Carol A Burke  1
Affiliations
Case Reports

Extraosseous Calcification of the Esophagus: Clinicopathologic Correlates of Esophageal Mucosal Calcinosis

Ari Garber et al. ACG Case Rep J. .

Abstract

Esophageal mucosal calcinosis (EMC) is a rare cause of dysphagia with high morbidity. We present a patient who experienced melena and 3 months of solid and liquid dysphagia along with bilateral lower extremity pain, erythema, and edema later determined to be calcific uremic arteriolopathy (CUA), or calciphylaxis. An esophagogastroduodenoscopy revealed nodularity and linear ulcerations in the upper third of the esophagus. Histology showed active inflammation and ulceration with small foci of subepithelial and intraepithelial calcification consistent with EMC. There is no known treatment for this disorder. Sodium thiosulfate, typically used to treat CUA, did not improve her dysphagia.

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Figures

Figure 1
Figure 1
Nodularity and ulceration in the upper esophagus.
Figure 2
Figure 2
Immunohistochemical stain showing (A) abundant dystrophic calcification within fibrinopurulent debris at the ulcer site (200x), (B) intact squamous mucosa with focal subepithelial calcification (200x), and (C) a detached fragment of squamous epithelium with intraepithelial calcification (400x).
See this image and copyright information in PMC

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