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Case Reports
. 2017 Sep 8;3(5):425-428.
doi: 10.1016/j.jdcr.2017.06.010. eCollection 2017 Sep.

Palisaded neutrophilic granulomatous dermatitis: Spectrum of histologic findings in a single patient

Jessica E Kalen  1 , Divya Shokeen  1 , Francisco Ramos-Caro  1 , Kiran Motaparthi  1
Affiliations
Case Reports

Palisaded neutrophilic granulomatous dermatitis: Spectrum of histologic findings in a single patient

Jessica E Kalen et al. JAAD Case Rep. .
No abstract available

Keywords: GA, granuloma annulare; PNGD, palisaded neutrophilic granulomatous dermatitis; RA, rheumatoid arthritis; palisaded neutrophilic granulomatous dermatitis; rheumatoid arthritis.

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Figures

Fig 1
Fig 1
A, Erythematous-to-violaceous plaques and nodules on the palmar surfaces, knees, and shins. B, Erythematous plaques on the extensor arms and dorsal hands.
Fig 2
Fig 2
Prominent papillary dermal edema overlying a mixed dermal infiltrate with abundant neutrophils. In isolation, these morphologic findings are strikingly similar to those of neutrophilic dermatoses, such as Sweet syndrome. (Hematoxylin-eosin stain; original magnifications: A, ×40; B, ×100; C, ×200.)
Fig 3
Fig 3
Interstitial and palisading granulomas surround foci of neutrophils with karyorrhectic debris; these features are readily identified as palisaded neutrophilic granulomatous dermatitis. (Hematoxylin-eosin stain; original magnifications: A, ×40; B, ×100; C, ×200.)
Fig 4
Fig 4
Palisading histiocytes surround degenerating collagen; increased dermal mucin and solar elastosis are also present. These morphologic findings closely resemble GA. (Hematoxylin-eosin stain; original magnifications: A, ×40; B, ×100; C, ×200.)
See this image and copyright information in PMC

References

    1. Chu P., Connolly M.K., LeBoit P.E. The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol. 1994;130:1278–1283. - PubMed
    1. Hawryluk E.B., Izikson L., English J.C., 3rd Non-infectious granulomatous diseases of the skin and their associated systemic diseases: an evidence-based update to important clinical questions. Am J Clin Dermatol. 2010;11:171–181. - PubMed
    1. Sangueza O.P., Caudell M.D., Mengesha Y.M. Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis. J Am Acad Dermatol. 2002;47:251–257. - PubMed
    1. Hunt R.D., Hartman R.D., Molho-Pessach V., Votava H.J., Schaffer J.V. Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. J Am Acad Dermatol. 2012;67:e164–e166. - PubMed
    1. Bremner R., Simpson E., White C.R., Morrison L., Deodhar A. Palisaded neutrophilic and granulomatous dermatitis: an unusual cutaneous manifestation of immune-mediated disorders. Semin Arthritis Rheum. 2004;34:610–616. - PubMed

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