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Review
. 2017 Oct;14(5):184-199.
doi: 10.1007/s11904-017-0364-x.

Redefining Aging in HIV Infection Using Phenotypes

David M Stoff  1 , Karl Goodkin  2 , Dilip Jeste  3 , Maria Marquine  3
Affiliations
Review

Redefining Aging in HIV Infection Using Phenotypes

David M Stoff et al. Curr HIV/AIDS Rep. 2017 Oct.

Abstract

Purpose of review: This article critically reviews the utility of "phenotypes" as behavioral descriptors in aging/HIV research that inform biological underpinnings and treatment development. We adopt a phenotypic redefinition of aging conceptualized within a broader context of HIV infection and of aging. Phenotypes are defined as dimensions of behavior, closely related to fundamental mechanisms, and, thus, may be more informative than chronological age. Primary emphasis in this review is given to comorbid aging and cognitive aging, though other phenotypes (i.e., disability, frailty, accelerated aging, successful aging) are also discussed in relation to comorbid aging and cognitive aging.

Recent findings: The main findings that emerged from this review are as follows: (1) the phenotypes, comorbid aging and cognitive aging, are distinct from each other, yet overlapping; (2) associative relationships are the rule in HIV for comorbid and cognitive aging phenotypes; and (3) HIV behavioral interventions for both comorbid aging and cognitive aging have been limited. Three paths for research progress are identified for phenotype-defined aging/HIV research (i.e., clinical and behavioral specification, biological mechanisms, intervention targets), and some important research questions are suggested within each of these research paths.

Keywords: Aging; Cognitive aging; Comorbid aging; HIV; Interventions; Phenotypes.

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Conflict of interest statement

Conflict of Interest

Karl Goodkin reports grant from Alkermes, pending grant from Janssen, and pending grant from Sunovion.

David M. Stoff, Dilip Jeste, and Maria Marquineo declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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