Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure

Abstract

Despite significant improvements in morbidity and mortality with current evidence-based pharmaceutical-based treatment of heart failure (HF) over the previous decades, the burden of HF remains high. An alternative approach is currently being developed, which targets myocardial energy efficiency and the dysfunction of the cardiac mitochondria. Emerging evidence suggests that the insufficient availability of ATP to the failing myocardium can be attributed to abnormalities in the myocardial utilisation of its substrates rather than an overall lack of substrate availability. Therefore, the development of potential metabolic therapeutics has commenced including trimetazidine, ranolazine and perhexiline, as well as specific mitochondrial-targeting pharmaceuticals, such as elamipretide. Large randomised controlled trials are required to confirm the role of metabolic-modulating drugs in the treatment of heart failure, but early studies have been promising in their possible efficacy for the management of heart failure in the future.

Keywords: elamipretide; heart failure; metabolic; mitochondria; perhexiline; ranolazine; trimetazidine.

Figure 1

Change Δ (treatment effect) effect between pretreatment and 12 weeks post-treatment for left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF) and fractional area of shortening (FAS) in heart failure control dogs and heart failure dogs treated with elamipretide. Statistical significance based on t-statistics for two means. Bar graph depicted as mean ± SEM [71].