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Editorial
. 2017;16(21):1999-2000.
doi: 10.1080/15384101.2017.1377501. Epub 2017 Sep 29.

Mtr4/ZFC3H1 protects polysomes through nuclear RNA surveillance

Koichi Ogami  1   2 , James L Manley  1
Affiliations
Editorial

Mtr4/ZFC3H1 protects polysomes through nuclear RNA surveillance

Koichi Ogami et al. Cell Cycle. 2017.
No abstract available

Keywords: Mtr4; RNA surveillance; ZFC3H1; exosome; lncRNA; polyadenylation; polysome.

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Figures

Figure 1.
Figure 1.
pt- and ua- RNAs are normally rapidly degraded in the nucleus by Mtr4/ZFC3H1. Mtr4/ZFC3H1 may inhibit nuclear export of its substrates by competing with ALYREF for ARS2/CBC association. Loss of the Mtr4/ZFC3H1 results in stabilization of pt- and ua- RNAs and increased ALYREF-ARS2/CBC interaction, and these RNAs accumulate in the cytoplasm, become ribosome-associated, and consequently, overwhelm the translation machinery.
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Comment on

References

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