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. 2018 Apr 1;197(7):949-952.
doi: 10.1164/rccm.201707-1446LE.

Endobronchial Optical Coherence Tomography for Low-Risk Microscopic Assessment and Diagnosis of Idiopathic Pulmonary Fibrosis In Vivo

Lida P Hariri  1   2 , David C Adams  1   2 , John C Wain  1   2 , Michael Lanuti  1   2 , Ashok Muniappan  1   2 , Amita Sharma  1   2 , Thomas V Colby  3 , Mari Mino-Kenudson  1   2 , Eugene J Mark  1   2 , Richard L Kradin  1   2 , Hannah Goulart  1 , Andrew M Tager  1   2 , Melissa J Suter  1   2
Affiliations

Endobronchial Optical Coherence Tomography for Low-Risk Microscopic Assessment and Diagnosis of Idiopathic Pulmonary Fibrosis In Vivo

Lida P Hariri et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
(A) In vivo endobronchial optical coherence tomography (OCT) accurately identified features of usual interstitial pneumonitis (UIP)/idiopathic pulmonary fibrosis (IPF), including multifocal microscopic honeycombing (HC, arrows) as layered cystic structures embedded within peripheral, destructive fibrosis (f) beyond the bronchiolar epithelium (e). (B) Subsequent surgical lung biopsies were independently diagnosed as UIP, and confirmed the presence of peripheral fibrosis (f) and microscopic honeycombing (arrows). (C) OCT accurately identified traction bronchiectasis (TB) as cystic airway branchpoints, and nondestructive interstitial fibrosis (IF) in alveolar walls in non-UIP/IPF interstitial lung disease (ILD). (D) Subsequent surgical lung biopsy independently confirmed all features visualized on OCT, including traction bronchiectasis (TB, right inset) and interstitial fibrosis (IF) in alveolar walls (left inset). No honeycombing or other UIP features were seen, and the biopsy was diagnosed as a non-UIP/IPF ILD.
Figure 2.
Figure 2.
(A) In vivo endobronchial optical coherence tomography (OCT) identified microscopic honeycombing (HC) and destructive peripheral fibrosis (f) in a patient with nondiagnostic high-resolution computed tomography and indeterminate lung biopsy. A branching bronchiole (B) is also visible. (B) OCT visualized spatial heterogeneity as regions of preserved alveoli (a) adjacent to fibrosis.
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